Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
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چکیده
منابع مشابه
Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
N-acetylcysteine is the classical antidote for acetaminophen overdose-induced hepatotoxicity, but its efficacy is limited by the need for early and only temporary treatment. Therefore, Yang and colleagues tested the hypothesis of whether ethyl pyruvate--another anti-inflammatory and antioxidant compound, which they had previously shown to protect against liver injury of various other etiologies...
متن کاملN-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملN-Acetylcysteine Overdose After Acetaminophen Poisoning
N-acetylcysteine (NAC) is a drug used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. In children considering the toxic dose of acetaminophen ingested by the patient and the body weight, the physician prescribes a specific dose of NAC. There is always a risk of iatrogenic overdose of NAC which can cause different mild to...
متن کاملThe hepatoprotective effect of N-acetylcysteine in acetaminophen intoxication is due to early glutathione replenishment via stimulation of anaplerotic mechanisms
T. Chan, V-A. Raymond, M. Bilodeau, D. Leibfritz, C. Zwingmann Centre de Recherche, Hospital Saint-Luc, Montreal, Quebec, Canada, Department of Organic Chemistry, University of Bremen, Bremen, Bremen, Germany Introduction. Acetaminophen (AAP) is converted by the cytochrome P450 pathway to a toxic intermediate, N-acetyl-p-benzoquinone-imine (NAPQI), which is usually completely detoxified through...
متن کاملN-acetylcysteine overdose after acetaminophen poisoning
N-acetylcysteine (NAC) is used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. Here we report a rare case of iatrogenic NAC overdose following an error in preparation of the solution, and describe its clinical symptoms. Laboratory results and are presented and examined. A 23-year-old alert female patient weighing 65 kg presented to the em...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2012
ISSN: 1364-8535
DOI: 10.1186/cc11153